Electrocardiogram markers of atrial and ventricular repolarization abnormalities and their association with symptom severity in antipsychotic-free patients with schizophrenia

Objective: Increased risk for arrhythmias and the association between arrhythmogenic markers symptom severity in antipsychotic-free patients with schizophrenia are understudied. We evaluated changes P-wave dispersion (PWD), corrected QT interval (QTc), QTc (QTcd), JT (JTc), JTc (JTcd), Tpeak-Tend (Tp-e), Tp-e/QT ratio. Method: Fifty-six who were at least 1 month 56 age- gendermatched healthy controls included. Illness-related characteristics such as Positive Negative Syndrome Scale (PANSS) scores recorded. Electrocardiography recordings performed standardized procedures all participants, of arrhythmia calculated from electrocardiograms. Results: PWD (p<0.001), QTcd (p=0.002), JTcd (p<0.001) values significantly increased compared to controls. Among ECG markers, was inversely correlated PANSS General subscale (r=-0.27, p<0.05), age illness onset (r=0.41, p=0.001). Conclusion: Changes ECG-derived cardiac arrhythmia, which acquired through an easy cheap method, can be predict prevent serious conditions patients.